A tumor cell-differentiating agent
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Hexamethylene bisacetamide

Item No. 30859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-1,6-hexanediylbis-acetamide
CAS Number
3073-59-4
Synonyms
  • HMBA
  • NSC 95580
Molecular Formula
C10H20N2O2
Formula Weight
200.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(NCCCCCCNC(C)=O)=O
InChi Code
InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
InChi Key
BNQSTAOJRULKNX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $102

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    $194

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    Cayman Chemical
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    Product Description

    Hexamethylene bisacetamide is a tumor cell-differentiating agent.1 It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner.2 Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven, but not 28, days reduces tumorigenesis of those cells in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reuben, R.C., Wife, R.L., Breslow, R., et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 73(3), 862-866 (1976).

    2. Contreras, X., Barboric, M., Lenasi, T., et al. HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. PLoS Pathog. 3(10), 1459-1469 (2007).

    3. Schroy, P., Winawer, S., and Friedman, E. Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamide. Cancer Lett. 48(1), 53-58 (1989).