An inhibitor of protein fucosylation
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2F-Peracetyl-Fucose

Item No. 30865

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dideoxy-2-fluoro-L-galactopyranose 1,3,4-triacetate
CAS Number
188783-78-0
Synonyms
  • 2F-PerAcFuc
  • 1,3,4-Tri-O-acetyl-2-deoxy-2-fluoro-L-fucose
Molecular Formula
C12H17FO7
Formula Weight
292.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: 10 mg/mlMethanol: soluble
SMILES
O=C(C)O[C@@H]([C@H]([C@@H]1F)OC(C)=O)[C@@H](OC1OC(C)=O)C
InChi Code
InChI=1S/C12H17FO7/c1-5-10(18-6(2)14)11(19-7(3)15)9(13)12(17-5)20-8(4)16/h5,9-12H,1-4H3/t5-,9-,10+,11-,12?/m0/s1
InChi Key
QFVJLBVULJFLKN-VLCHEQJQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $242

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    100 mg

    $412

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    250 mg

    $968

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    Product Description

    2F-Peracetyl-fucose is an inhibitor of protein fucosylation.1 It inhibits fucosylation of IgG1 monoclonal antibodies produced by CHO-DG44 cells when used at a concentration of 50 µM. It reduces intracellular GDP-fucose levels in CHO-DG44 cells in a concentration-dependent manner. 2F-Peracetyl-fucose (100 µM) also decreases intracellular fucose levels in A. thaliana seedlings.2 2F-Peracetyl-fucose decreases root length in A. thaliana seedlings in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okeley, N.M., Alley, S.C., Anderson, M.E., et al. Development of orally active inhibitors of protein and cellular fucosylation. Proc. Natl. Acad. Sci. USA 110(14), 5404-5409 (2013).

    2. Villalobos, J.A., Yi, B.R., and Wallace, I.S. 2-Fluoro-L-fucose is a metabolically incorporated inhibitor of plant cell wall polysaccharide fucosylation. PLoS One 10(9), e0139091 (2015).