An ERG inhibitor
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ERGi-USU

Item No. 30875

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(2-thiazolyl)diazenyl]-2-naphthalenol
CAS Number
1147-56-4
Synonyms
  • NSC 139021
Molecular Formula
C13H9N3OS
Formula Weight
255.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMSO: 5mg/mLEthanol: 0.5mg/mL
λmax
213, 226, 482 nm
SMILES
OC1=C(/N=N/C2=NC=CS2)C(C=CC=C3)=C3C=C1
InChi Code
InChI=1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H/b16-15+
InChi Key
IOMXCGDXEUDZAK-FOCLMDBBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $37

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    100 mg

    $50

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    500 mg

    $158

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    1 g

    $209

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    Cayman Chemical
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    Product Description

    ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG; IC50 = 315 nM).1 It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells (HUVECs), which do not express ERG (IC50s = >10 µM for all). ERGi-USU (100 and 150 mg/kg) reduces tumor growth in a VCaP mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mohamed, A.A., Xavier, C.P., Sukumar, G., et al. Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 78(13), 3659-3671 (2018).