An agonist of GluR5
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ATPA (hydrate)

Item No. 30882

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-4-isoxazolepropanoic acid, hydrate
Molecular Formula
C10H16N2O4 • XH2O
Formula Weight
228.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 10 mM
SMILES
NC(C(O)=O)CC1=C(C(C)(C)C)ONC1=O.O
InChi Code
InChI=1S/C10H16N2O4.H2O/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15;/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15);1H2
InChi Key
LKJZQCPVIAFMPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $81

    Add

    5 mg

    $357

    Add
    Product Description

    ATPA is an agonist of ionotropic glutamate receptor 5 (GluR5/GluK1; Ki = 0.0043 µM).1 It is selective for GluR5 over GluR1-4 (Kis = 6-14 µM), as well as GluR6 (Ki = >1,000 µM). ATPA induces inward currents in HEK293 cells expressing recombinant human GluR5 and isolated rat dorsal root ganglion (DRG) neurons (EC50s = 2.1 and 0.6 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clarke, V.R., Ballyk, B.A., Hoo, K.H., et al. A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 389(6651), 599-603 (1997).