An alkaloid with antiarrhythmic activities
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Denudatine

Item No. 30904

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,6aS,6bS,7S,8R,10R,10aS,11R,11aR,13R)-1-ethyldodecahydro-3-methyl-9-methylene-8,10a-ethano-11,3,6a-ethanylylidene-8H-indeno[2,1-b]azocine-7,10-diol
CAS Number
26166-37-0
Molecular Formula
C22H33NO2
Formula Weight
343.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: soluble
SMILES
O[C@@H]1[C@@]2([H])[C@@]([C@@H]3C4)(CCC[C@]35C)[C@@](N(C5)CC)([H])[C@H]4[C@]2(CC[C@@H]1C6=C)[C@@H]6O
InChi Code
InChI=1S/C22H33NO2/c1-4-23-11-20(3)7-5-8-22-15(20)10-14(18(22)23)21-9-6-13(12(2)19(21)25)16(24)17(21)22/h13-19,24-25H,2,4-11H2,1,3H3/t13-,14+,15-,16+,17-,18-,19-,20+,21+,22+/m1/s1
InChi Key
OVXLNQAYPUEDSI-ZAWREGRRSA-N
Origin
Plant/Aconitum carmichaelii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $197

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    10 mg

    $367

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    25 mg

    $783

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    Product Description

    Denudatine is an alkaloid that has been found in A. jinyangense and has antiarrhythmic activity.1 In vivo, denudatine (50 and 100 mg/kg) prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jin, L.S., Zhou, Y.P., and Zeng, G.Y. Effects of denudatine on experimental arrhythmia and heart function. Zhongguo Yao Li Xue Bao 3(2), 104-108 (1982).