A xanthone with diverse biological activities
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Garcinone D

Item No. 30906

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number
107390-08-9
Molecular Formula
C24H28O7
Formula Weight
428.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mg/ml
λmax
244, 318 nm
SMILES
O=C1C2=C(C=C(O)C(OC)=C2CCC(C)(O)C)OC3=CC(O)=C(C/C=C(C)/C)C(O)=C31
InChi Code
InChI=1S/C24H28O7/c1-12(2)6-7-13-15(25)10-18-20(21(13)27)22(28)19-14(8-9-24(3,4)29)23(30-5)16(26)11-17(19)31-18/h6,10-11,25-27,29H,7-9H2,1-5H3
InChi Key
TYALNCRUIKOKGP-UHFFFAOYSA-N
Origin
Plant/Garcinia mangostana L.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $263

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    10 mg

    $297

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    25 mg

    $575

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    Product Description

    Garcinone D is a xanthone that has been found in G. mangostana and has diverse biological activities.1 It increases proliferation of C17.2 neural progenitor cells (NPCs) when used at a concentration of 5 µM, an effect that can be reduced by inhibition of the antioxidative transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). It increases phosphorylation of STAT3 and cyclin D1 and the protein levels of Nrf2 and heme oxygenase-1 (HO-1) in a concentration-dependent manner. Garcinone D (3 µM) inhibits aggregation of amyloid-β (1-42) (Aβ42; Item No. 20574) in vitro and inhibits beta-secretase 1 (BACE1) by 62.7% when used at a concentration of 100 µM.2 It scavenges peroxynitrite radicals with an IC50 value of 26.4 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, X., Wang, S., Ouyang, Y., et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Nuerosci. Lett. 626, 6-12 (2016).

    2. Wang, S.-N., Li, Q., Jing, M.-H., et al. Natural xanthones from Garcinia mangostana with multifunctional activities for the therapy of Alzheimer’s disease. Neurochem. Res. 41(7), 1806-1817 (2016).

    3. Jung, H.-A., Su, B.-N., and Keller, W. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J. Agric. Food Chem. 54(6), 2077-2082 (2006).