An activator of PKC
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SC-9

Item No. 30910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide
CAS Number
102649-78-5
Molecular Formula
C22H24ClNO2S
Formula Weight
402.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: slightly solubleChloroform: slightly soluble
SMILES
O=S(NCCCCCCC1=CC=CC=C1)(C2=CC=CC3=C2C=CC=C3Cl)=O
InChi Code
InChI=1S/C22H24ClNO2S/c23-21-15-8-14-20-19(21)13-9-16-22(20)27(25,26)24-17-7-2-1-4-10-18-11-5-3-6-12-18/h3,5-6,8-9,11-16,24H,1-2,4,7,10,17H2
InChi Key
YUXMTDYHFPRPLG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $80

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    10 mg

    $140

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    Product Description

    SC-9 is an activator of protein kinase C (PKC).1 It is selective for PKC over myosin light-chain kinase (MLCK), PKA, and PKG at 300 µM. SC-9 (200 µM) increases PKC-induced MLC phosphorylation in the presence of calcium.2 It induces proliferation of quiescent primary neonatal mouse epidermal melanoblasts when used at a concentration of 10 µM.3 SC-9 (2.5-20 µM) reduces the motility of isolated intact chicken sperm.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, M., Tanaka, T., Inagaki, M., et al. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry 25(15), 4179-4184 (1986).

    2. Nishino, H., Kitagawa, K., Iwashima, A., et al. N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase. Biochim. Biophys. Acta 889(2), 236-239 (1986).

    3. Hirobe, T. Effects of activators (SC-9 and OAG) and inhibitors (staurosporine and H-7) of protein kinase C on the proliferation of mouse epidermal melanoblasts in serum-free culture. J. Cell Sci. 107(Pt 6), 1679-1686 (1994).

    4. Ashizawa, K., Katayama, S., Kobayashi, T., et al. Possible role of protein kinase C in regulation of flagellar motility and intracellular free Ca2+ concentration of fowl spermatozoa. J. Reprod. Fertil. 101(3), 511-517 (1994).