A calcimimetic and positive allosteric modulator of CaSR
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AC-265347

Item No. 30937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(2,4-dimethylphenyl)-α-methyl-2-benzothiazolemethanol
CAS Number
1253901-26-6
Molecular Formula
C17H17NOS
Formula Weight
283.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 100 mM
SMILES
CC1=CC(C)=CC=C1C(C)(O)C2=NC3=CC=CC=C3S2
InChi Code
InChI=1S/C17H17NOS/c1-11-8-9-13(12(2)10-11)17(3,19)16-18-14-6-4-5-7-15(14)20-16/h4-10,19H,1-3H3
InChi Key
IGSZVEPQZANNAB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $95

    Add
    Product Description

    AC-265347 is a calcimimetic and positive allosteric modulator of the calcium-sensing receptor (CaSR; EC50 = 7.94 nM in a cell-based phosphatidylinositol hydrolysis assay in the presence of calcium).1,2 It inhibits the proliferation of NIH3T3 cells expressing human CaSR (EC50 = 25.12 nM).1 AC-265347 reduces plasma parathyroid hormone levels in rats (ED50 = 0.01 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, J.N., Owens, M., Gustafsson, M., et al. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J. Pharmacol. Exp. Ther. 337(1), 275-284 (2011).

    2. Leach, K., Gregory, K.J., Kufareva, I., et al. Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor. Cell Res. 26(5), 574-592 (2016).