An activator of SERCA2A sumoylation
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N106

Item No. 30952

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-2-benzothiazolamine
CAS Number
862974-25-2
Molecular Formula
C17H14N4O3S
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
SMILES
COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1COC1=C(N=C(NC2=NN=C(C3=CC=C(OC)C=C3)O2)S4)C4=CC=C1
InChi Code
InChI=1S/C17H14N4O3S/c1-22-11-8-6-10(7-9-11)15-20-21-16(24-15)19-17-18-14-12(23-2)4-3-5-13(14)25-17/h3-9H,1-2H3,(H,18,19,21)
InChi Key
FBCSWQRNKAYAGY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $154

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    10 mg

    $283

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    25 mg

    $645

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    Product Description

    N106 is an activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2A (SERCA2A) SUMOylation.1 It activates SUMO-activating enzyme E1, which increases SUMOylation and the activity of SERCA2A in isolated adult rat cardiomyocytes when used at concentrations ranging from 0.1 to 1 µM. N106 increases contractility in the same cells. In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation and contractility in a mouse model of pressure overload-induced heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kho, C., Lee, A., Jeong, D., et al. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat. Commun. 6, 7229 (2015).