A CXCR4 agonist
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NUCC-390 (hydrochloride)

Item No. 30957

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-piperidinyl[4,5,6,7-tetrahydro-1-propyl-5-[[2-(4-pyridinyl)ethyl]amino]-1H-indazol-3-yl]-methanone, dihydrochloride
CAS Number
2749281-71-6
Molecular Formula
C23H33N5O • 2HCl
Formula Weight
468.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CCCN1N=C(C(N2CCCCC2)=O)C3=C1CCC(C3)NCCC4=CC=NC=C4.Cl.Cl
InChi Code
InChI=1S/C23H33N5O.2ClH/c1-2-14-28-21-7-6-19(25-13-10-18-8-11-24-12-9-18)17-20(21)22(26-28)23(29)27-15-4-3-5-16-27;;/h8-9,11-12,19,25H,2-7,10,13-17H2,1H3;2*1H
InChi Key
RSYDQYPPGGIWOJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

    $158

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    Product Description

    NUCC-390 is a chemokine (C-X-C motif) receptor 4 (CXCR4) agonist.1 It induces calcium mobilization in C8161 melanoma cells expressing CXCR4 when used at a concentration of 10 µM, an effect that can be prevented by the CXCR4 antagonist AMD3100 (plerixafor; Item No. 10011332). NUCC-390 (0.0625, 0.125, and 0.25 µM) increases axon length in cultured rat spinal cord motor neurons.2 In vivo, NUCC-390 (26 mg/kg per day) restores gastrocnemius muscle compound muscle action potentials (CMAPs) in a mouse model of sciatic nerve crush injury. It also restores CMAPs in a mouse model of neuroparalysis induced by Papuan taipan (O. scutellatus) venom.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mishra, R.K., Shum, A.K., Platanias, L.C., et al. Discovery and characterization of novel small-molecule CXCR4 receptor agonists and antagonists. Sci. Rep. 6:30155, 1-9 (2016).

    2. Zanetti, G., Negro, S., Megighian, A., et al. A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage. Ann. Clin. Transl. Neurol. 6(12), 2395-2402 (2019).

    3. Stazi, M., D'Este, G., Mattarei, A., et al. An agonist of the CXCR4 receptor accelerates the recovery from the peripheral neuroparalysis induced by Taipan snake envenomation. PLoS Negl. Trop. Dis. 14(9), e0008547 (2020).