An inhibitor of the IFN-α-IFNAR protein-protein interaction
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IFN-α-IFNAR-IN-1 (hydrochloride)

Item No. 30960

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-2-(1-naphthalenylthio)-benzenemethanamine, monohydrochloride
CAS Number
2070014-98-9
Molecular Formula
C18H17NS • HCl
Formula Weight
315.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/ml
λmax
223 nm
SMILES
CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C18H17NS.ClH/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18;/h2-12,19H,13H2,1H3;1H
InChi Key
QTESJCPDPNGOLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $631

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    Cayman Chemical
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    Product Description

    IFN-α-IFNAR-IN-1 is an inhibitor of the protein-protein interaction between the cytokine IFN-α and the IFN-α/β receptor (IFNAR; Kd = 4 µM for binding to IFN-α).1 It inhibits virus-induced increases in the production of IFN-α and IL-12 in bone marrow-derived plasmacytoid dendritic cells (BM-pDCs) infected with modified Vaccinia virus Ankara (MVA) or vesicular stomatitis virus (VSV) when used at a concentration of 18 µM. IFN-α-IFNAR-IN-1 also reduces increases in IL-12 production induced by stimulation with the toll-like receptor 9 (TLR9) agonist CpG 2216 or the TLR3 agonist poly(I:C) in the same cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Geppert, T., Bauer, S., Hiss, J.A., et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Agnew. Chem. Int. Ed. Engl. 51(1), 258-261 (2012).