A partial agonist of muscarinic acetylcholine receptors
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McNA343

Item No. 30961

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[(3-chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monochloride
CAS Number
55-45-8
Molecular Formula
C14H18ClN2O2 • Cl
Formula Weight
317.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
239 nm
SMILES
ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-]
InChi Code
InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
InChi Key
CXFZFEJJLNLOTA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $35

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    25 mg

    $63

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    50 mg

    $98

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    Product Description

    McNA343 is a partial agonist of muscarinic acetylcholine receptors (Kis = 5, 1, 5, 0.2, and 7.6 µM for M1-5 receptors, respectively, in radioligand binding assays).1 It induces contraction of isolated human umbilical veins (EC50 = 1.23 µM), an effect that can be reversed by various M1 muscarinic receptor selective antagonists. McNA343 also inhibits forskolin-induced cAMP production in CHO cells expressing M1 or M4 receptors, as well as phosphatidylinositol hydrolysis in CHO-K1 cells expressing M3 receptors and CHO cells expressing M5 receptors. Intrathecal administration of McNA343 inhibits compulsive hindlimb neck-scratching behavior induced by 5’-guanidinonaltrindole (GNTI) in mice. It has nootropic activity, enhancing spontaneous working memory in the Y maze in wild-type mice, and it reverses learning and memory impairments induced by bulbectomy in mice in a passive avoidance test.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mitchelson, F.J. The pharmacology of McN-A-343. Pharmacol. Ther. 135(2), 216-245 (2012).