A 5-HT4 receptor agonist
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BIMU 8

Item No. 30964

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide, monohydrochloride
CAS Number
134296-40-5
Molecular Formula
C19H26N4O2 • HCl
Formula Weight
378.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 75 mM
SMILES
O=C(N1C(N(C(C)C)C2=C1C=CC=C2)=O)N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3.Cl
InChi Code
InChI=1S/C19H26N4O2.ClH/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H/t13-,14+,15-;
InChi Key
NQYXXIUVFVOJCX-NFWSUKNGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    BIMU 8 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69 nM).1 It also binds 5-HT3 receptors (Ki = 0.36 nM). It stimulates cAMP formation in primary mouse embryonic colliculi neurons with an EC50 value of 72 nM.2 BIMU 8 (30, 40, and 60 nmol/animal, i.c.v.) induces acetylcholine release in the rat frontal cortex.3 It increases postprandial antral and colonic motility in conscious dogs when administered at doses of 0.1, 0.3, and 1 mg/kg.4 BIMU 8 (20 mg/kg, i.p.) also increases the latency to withdraw in the paw pressure test in rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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