An NMDA receptor antagonist
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Cerestat

Item No. 30966

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-ethylphenyl)-N-methyl-N′-1-naphthalenyl-guanidine, monohydrochloride
CAS Number
137160-11-3
Synonyms
  • CNS 1102
Molecular Formula
C20H21N3 • HCl
Formula Weight
339.9
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
N=C(N(C)C1=CC(CC)=CC=C1)NC2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C20H21N3.ClH/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19;/h4-14H,3H2,1-2H3,(H2,21,22);1H
InChi Key
CKAKVKWRMCAYJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $214

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    Product Description

    Cerestat is an NMDA receptor antagonist (IC50 = 36 nM).1 It is selective for the NMDA receptor over sigma receptors (IC50 = 2,540 nM). Cerestat (1 mg/kg) reduces infarct volume and the number of steps and errors in a foot fault test in a rat model of stroke induced by middle cerebral artery occlusion.2 It also reduces cortical and striatal neuronal necrosis in a rat model of temporary focal ischemia when administered at a dose of 1.13 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reddy, N.L., Hu, L.-Y., Cotter, R.E., et al. Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: A new, selective noncompetitive NMDA receptor antagonist. J. Med. Chem. 37(2), 260-267 (1994).

    2. Pitsikas, N., Brambilla, A., Besozzi, C., et al. Effects of cerestat and NBQX on functional and morphological outcomes in rat focal cerebral ischemia. Pharmacol. Biochem. Behav. 68(3), 443-447 (2000).

    3. Schäbitz, W.R., Li, F., and Fisher, M. The N-methyl-Ⅾ-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31(7), 1709-1714 (2000).