An inhibitor of platelet aggregation
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YS-49

Item No. 30970

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol, monohydrobromide
CAS Number
132836-42-1
Molecular Formula
C20H19NO2 • HBr
Formula Weight
386.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
225 nm
SMILES
OC1=C(O)C=C(CCNC2CC3=C(C=CC=C4)C4=CC=C3)C2=C1.Br
InChi Code
InChI=1S/C20H19NO2.BrH/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;/h1-7,11-12,18,21-23H,8-10H2;1H
InChi Key
JXFRKNGQHAAJKY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    YS-49 is an inhibitor of platelet aggregation.1 It inhibits ADP-, collagen-, or epinephrine-induced platelet aggregation in isolated human platelets (IC50s = 730, 92, and 3.4 µM, respectively). YS-49 also inhibits platelet aggregation and production of thromboxane A2 (TXA2) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in isolated rat platelets (IC50s = 3.3 and 32.8 µM, respectively).2 It reduces LPS-induced contractions in isolated endothelium-denuded rat aortic strips in a concentration-dependent manner.3 YS-49 (50 mg/kg) decreases thrombus weight in a rat model of arterio-venous shunt thrombosis.1 It increases survival in a mouse model of septicemia induced by LPS when administered at doses of 10 and 20 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yun-Choi, H.S., Pyo, M.K., Park, K.M., et al. Antithrombotic effects of YS-49 and YS-51--1-naphthylmethyl analogs of higenamine. Thromb. Res. 104(4), 249-255 (2001).

    2. Pyo, M.K., Kim, J.M., Jin, J.-L., et al. Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation. Thromb. Res. 120(1), 81-86 (2007).

    3. Kang, Y.J., Koo, E.B., Lee, Y.S., et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br. J. Pharmacol. 128(2), 357-364 (1999).