An alkaloid with diverse biological activities
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Dehydrocorydaline (chloride)

Item No. 30972

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-dibenzo[a,g]quinolizinium, monochloride
CAS Number
10605-03-5
Molecular Formula
C22H24NO4 • Cl
Formula Weight
401.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/ml
SMILES
COC1=CC=C2C(C=[N+](CCC3=CC(OC)=C(OC)C=C34)C4=C2C)=C1OC.[Cl-]
InChi Code
InChI=1S/C22H24NO4.ClH/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23;/h6-7,10-12H,8-9H2,1-5H3;1H/q+1;/p-1
InChi Key
WXOSEFNJXIPZNV-UHFFFAOYSA-M
Origin
Plant/Corydalis yanhusuo
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $323

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    10 mg

    $609

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    Product Description

    Dehydrocorydaline is an alkaloid that has been found in C. yanhusuo and has diverse biological activities.1,2,3,4 Dehydrocorydaline inhibits serotonin (5-HT; Item No. 14332) reuptake by organic cation transporter 2 (OCT2) and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes.2 In vivo, dehydrocorydaline (1.5 and 3 mg/kg) decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress. Dehydrocorydaline (10 mg/kg) reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwasa, K., Moriyasu, M., and Nader, B. Fungicidal and herbicidal activities of berberine related alkaloids. Biosci. Biotechnol. Biochem. 64(9), 1998-2000 (2000).

    2. Jin, L., Zhou, S., Zhu, S., et al. Dehydrocorydaline induced antidepressant-like effect in a chronic unpredictable mild stress mouse model via inhibiting uptake-2 monoamine transporters. Eur. J. Pharmacol. 864, 172725 (2019).

    3. Yin, Z.-Y., Li, L., Chu, S.-S., et al. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci. Rep. 6, 27129 (2016).

    4. Huo, W., Zhang, Y., Liu, Y., et al. Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype. Mol. Pain 14, 1744806918781733 (2018).