A peptide ETB receptor agonist
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IRL 1620 (trifluoroacetate salt)

Item No. 30980

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan, trifluoroacetate salt
Synonyms
  • PMZ-1620
  • SPI 1620
  • Suc-[Glu9, Ala11,15]-ET-1(8-21)
Molecular Formula
C86H117N17O27 • XCF3COOH
Formula Weight
1820.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C86H117N17O27.C2HF3O2/c1-11-44(7)71(84(127)100-63(86(129)130)35-50-39-88-54-21-17-16-20-53(50)54)103-85(128)72(45(8)12-2)102-82(125)62(38-69(114)115)98-78(121)57(32-42(3)4)96-80(123)60(36-51-40-87-41-89-51)95-73(116)46(9)91-77(120)58(33-48-18-14-13-15-19-48)97-79(122)59(34-49-22-24-52(104)25-23-49)99-83(126)70(43(5)6)101-74(117)47(10)90-75(118)55(26-29-65(106)107)93-76(119)56(27-30-66(108)109)94-81(124)61(37-68(112)113)92-64(105)28-31-67(110)111;3-2(4,5)1(6)7/h13-25,39-47,55-63,70-72,88,104H,11-12,26-38H2,1-10H3,(H,87,89)(H,90,118)(H,91,120)(H,92,105)(H,93,119)(H,94,124)(H,95,116)(H,96,123)(H,97,122)(H,98,121)(H,99,126)(H,100,127)(H,101,117)(H,102,125)(H,103,128)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H,129,130);(H,6,7)/t44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,70-,71-,72-;/m0./s1
InChi Key
UNWVRNMZMQCAAV-DWPPSSTPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $107

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    1 mg

    $171

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    5 mg

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    Product Description

    IRL 1620 is a peptide endothelin type B (ETB) receptor agonist.1 It selectively binds to ETB receptors (Ki = 16 pM) over ETA receptors (IC50 = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.2 It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.3 IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takai, M., Umemura, I., Yamasaki, K., et al. A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem. Biophys. Res. Commun. 184(2), 953-959 (1992).

    2. James, A.F., Urade, Y., Webb, R.L., et al. IRL 1620, succinyl-[Glu9,Ala11,15]-endothelin-1(8-21), a highly specific agonist of the ETB receptor. Cardiovasc. Drug Rev. 11(3), 253-270 (1993).

    3. Gulati, A., Hornick, M.G., Briyal, S., et al. A novel neuroregenerative approach using ETB receptor agonist, IRL-1620, to treat CNS disorders. Physiol. Res. 67(Suppl 1), S95-S113 (2018).