A Wnt5a peptide mimetic
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Foxy-5 (trifluoroacetate salt)

Item No. 30983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-formyl-L-methionyl-L-α-aspartylglycyl-L-cysteinyl-L-α-glutamyl-L-leucine
Synonyms
  • N-formyl-Met-Asp-Gly-Cys-Glu-Leu
  • N-formyl-MDGCEL
Molecular Formula
C26H42N6O12S2 • XCF3COOH
Formula Weight
694.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: SolublePBS (pH 7.4): 1 mg/ml
SMILES
O=C(N[C@H](C(O)=O)CC(C)C)[C@H](CCC(O)=O)NC([C@H](CS)NC(CNC([C@H](CC(O)=O)NC([C@@H](NC=O)CCSC)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C26H42N6O12S2.C2HF3O2/c1-13(2)8-17(26(43)44)32-24(41)15(4-5-20(35)36)30-25(42)18(11-45)29-19(34)10-27-22(39)16(9-21(37)38)31-23(40)14(28-12-33)6-7-46-3;3-2(4,5)1(6)7/h12-18,45H,4-11H2,1-3H3,(H,27,39)(H,28,33)(H,29,34)(H,30,42)(H,31,40)(H,32,41)(H,35,36)(H,37,38)(H,43,44);(H,6,7)/t14-,15-,16-,17-,18-;/m0./s1
InChi Key
CLBGNYFFUUHBLL-HGIJKBOGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $268

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    25 mg

    $587

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    Cayman Chemical
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    Product Description

    Foxy-5 is a Wnt5a peptide mimetic with anticancer activity.1,2 It increases adhesion and reduces cell motility of MDA-MB-468 breast cancer cells when used at concentrations ranging from 1 to 1,000 µM.1 Foxy-5 (2 mg/kg) reduces the number of lymph node metastases without affecting primary tumor growth in a DU145-Luc mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Säfholm, A., Leandersson, K., Dejmek, J., et al. A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. The Journal of Biological Chemisty 281(5), 2740-2749 (2006).

    2. Canesin, G., Evans-Axelsson, S., Hellsten, R., et al. Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One 12(9), e0184418 (2017).