A peptide agonist of GnRH
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Alarelin (acetate)

Item No. 30993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-D-alanine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (swine), diacetate
CAS Number
79561-22-1
Synonyms
  • pGlu-HWSYALRP-NHEt
  • [D-Ala6, des-Gly10]GnRH-ethylamide
  • des-Gly GnRH
Molecular Formula
C56H78N16O12 • 2C2H4O2
Formula Weight
1287.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
221 nm
SMILES
O=C(N[C@@H](CO)C(N[C@H](C(N[C@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N(CCC1)[C@@H]1C(NCC)=O)=O)=O)=O)=O)CC(C=C2)=CC=C2O)=O)[C@@H](NC([C@@H](NC([C@H](CC3)NC3=O)=O)CC4=CN=CN4)=O)CC5=CNC6=CC=CC=C56.CC(O)=O.CC(O)=O
InChi Code
InChI=1S/C56H78N16O12.2C2H4O2/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38;2*1-2(3)4/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61);2*1H3,(H,3,4)/t31-,38+,39+,40+,41+,42+,43+,44+,45+;;/m1../s1
InChi Key
DPWSRXJWCYEGIV-PFHUABGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Alarelin is a peptide agonist of gonadotropin-releasing hormone (GnRH).1 It binds to the GnRH receptor (GnRHR) with a Kd value of 0.2 nM. Alarelin (6 ng, i.c.v.) decreases the expression of GnRH in the preoptic area and GnRHR in the posterior mediobasal hypothalamus (pMBH) of ovariectomized estradiol-treated rats, indicating an ultrashort negative feedback loop on GnRH and GnRHR gene expression.2 It induces desensitization in the pituitary and decreases serum estradiol levels and ovarian and uterine weight in neonatal and adult female rats.3 Alarelin reduces tumor growth in an HEC-1-B human endometrial carcinoma mouse xenograft model when administered at doses of 20, 40, and 80 µg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nederpelt, I., Georgi, V., Schiele, F., et al. Characterization of 12 GnRH peptide agonists - a kinetic perspective. Br. J. Pharmacol. 173(1), 128-141 (2016).

    2. Han, Y.-G., Kang, S.S., Seong, J.Y., et al. Negative regulation of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression by a gonadotrophin-releasing hormone agonist in the rat hypothalamus. J. Neuroendocrinol. 11(3), 195-201 (1999).

    3. Trimiño, E., Pinilla, L., and Aguilar, E. Pituitary-gonadal function in neonatal and adult female rats treated with gonadotropin-releasing hormone agonist and antagonist: Short- and long-term effects. Acta Endocrinol. (Copenh.) 129(3), 251-259 (1993).

    4. Xiaoying, X., and Sanyuan, Z. Effect of alarelin acetate on human endometrial carcinoma in nude mice transplantation tumor and expression of POT1. Zhonghua Linchuang Yishi Zazhi 9(7), 63-66 (2015).