A SHP-2 inhibitor
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RMC-4550

Item No. 31011

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]dec-8-yl]-6-(2,3-dichlorophenyl)-5-methyl-2-pyrazinemethanol
CAS Number
2172651-73-7
Molecular Formula
C21H26Cl2N4O2
Formula Weight
437.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10 mg/mlDMSO: soluble
SMILES
ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4([C@H](N)[C@H](C)OC4)CC3)N=C2C)=CC=C1
InChi Code
InChI=1S/C21H26Cl2N4O2/c1-12-18(14-4-3-5-15(22)17(14)23)26-16(10-28)20(25-12)27-8-6-21(7-9-27)11-29-13(2)19(21)24/h3-5,13,19,28H,6-11,24H2,1-2H3/t13-,19+/m0/s1
InChi Key
IKUYEYLZXGGCRD-ORAYPTAESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    RMC-4550 is an inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2; IC50 = 1.55 nM).1 It is selective for SHP-2 over a panel of 14 additional protein phosphatases and a panel of 468 protein kinases at 10 µM. It inhibits tumor ERK phosphorylation in a KYSE-520 human esophageal cancer xenograft model in a dose-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koltun, E.S., Aay, N., Buckl, A., et al. RMC-4550, an allosteric inhibitor of SHP2: Synthesis, structure, and anti-tumor activity. Cancer Res. 78(13 Suppl.), (2018).