An internal standard for the quantification of prostaglandin A2
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Unlabeled Version(s)
10210Prostaglandin A2
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Prostaglandin A2-d4

Item No. 310210

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-15S-hydroxy-prosta-5Z,10,13E-trien-1-oic-3,3,4,4-d4 acid
CAS Number
201608-18-6
Synonyms
  • PGA2-d4
  • Medullin-d4
Molecular Formula
C20H26D4O4
Formula Weight
338.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 500 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 75 mg/mlDMSO: 50 mg/mlEthanol: 100 mg/mlPBS pH 7.2: 2.4 mg/ml
λmax
216 nm
SMILES
O=C1[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1
InChi Code
InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1/i5D2,8D2
InChi Key
MYHXHCUNDDAEOZ-IDCRMVQDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $49

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    100 µg

    $93

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    500 µg

    $423

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    1 mg

    $748

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    Product Description

    Prostaglandin A2-d4 (PGA2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGA2 by GC- or LC- mass spectrometry. PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. It has low biological potency in most bioassays, but does show some antiviral/antitumor activity.1 At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase.2 It has also been shown to act as a vasodilator with natriuretic properties.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukushima, M., Kato, T., Narumiya, S., et al. Prostaglandin A and J: Antitumor and antiviral prostaglandins. Adv. Prostaglandin Thromboxane Leukot. Res. 19, 415-418 (1989).

    2. Hitomi, M., Shu, J., Strom, D., et al. Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. The Journal of Biological Chemisty 271(16), 9376-9383 (1996).

    3. Frolich, J.C., Sweetman, B.J., Carr, K., et al. Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometry. Prostaglandins 10(1), 185-195 (1975).