A cGAS inhibitor
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CU-76

Item No. 31030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate
CAS Number
2400954-58-5
Molecular Formula
C11H8F2IN5O2
Formula Weight
407.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml
λmax
264 nm
SMILES
IC1=C(F)C=C(NC2=NC(N)=NC(C(OC)=O)=N2)C=C1F
InChi Code
InChI=1S/C11H8F2IN5O2/c1-21-9(20)8-17-10(15)19-11(18-8)16-4-2-5(12)7(14)6(13)3-4/h2-3H,1H3,(H3,15,16,17,18,19)
InChi Key
DATILFYUDSRBBK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

    $306

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    10 mg

    $523

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    Cayman Chemical
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    Product Description

    CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50 = 0.24 µM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3; Item No. 22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Padilla-Salinas, R., Sun, L., Anderson, R., et al. Discovery of small-molecule cyclic GMP-AMP synthase inhibitors. The Journal of Organic Chemistry 85(3), 1579-1600 (2020).