An IKKβ NBD mimetic
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SR 12343

Item No. 31031

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(3-bromophenyl)ethyl]-2-[(5-chloro-2-pyridinyl)amino]-acetamide
CAS Number
2055101-86-3
Molecular Formula
C15H15BrClN3O
Formula Weight
368.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
249 nm
SMILES
ClC1=CN=C(NCC(NCCC2=CC(Br)=CC=C2)=O)C=C1
InChi Code
InChI=1S/C15H15BrClN3O/c16-12-3-1-2-11(8-12)6-7-18-15(21)10-20-14-5-4-13(17)9-19-14/h1-5,8-9H,6-7,10H2,(H,18,21)(H,19,20)
InChi Key
PEOFCAIUELALCR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $66

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    5 mg

    $165

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    10 mg

    $264

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    25 mg

    $578

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    Cayman Chemical
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    Product Description

    SR 12343 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It selectively disrupts the association of NEMO/IKKγ with IKKβ over TNF receptor-associated factor 2 (TRAF2), IκBα, and IKKα in co-immunoprecipitation assays using RAW 264.7 cells at concentrations ranging from 25 to 150 µM. SR 12343 inhibits TNF-α-induced NF-κB activation in a reporter assay. It reduces increased serum IL-6 levels in a mouse model of LPS-induced endotoxemia when administered at a dose of 10 mg/kg. SR 12343 (30 mg/kg) improves grip strength and reduces muscle fibrosis in the mdx mouse model of Duchenne muscular dystrophy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, J., Zhang, L., Mu, X., et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activation. PLoS Biol. 16(6), e2004663 (2018).