An inhibitor of LAT1
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KMH-233

Item No. 31032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-L-phenylalanine
CAS Number
1941174-13-5
Molecular Formula
C32H25N7O5
Formula Weight
587.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C([C@H](CC1=CC=CC(C(NC2=C(C(C3=CC=C(C=C3)OCC(NC)=O)=C(C4=NC5=CC=CC=C5N24)C#N)C#N)=O)=C1)N)O
InChi Code
InChI=1S/C32H25N7O5/c1-36-27(40)17-44-21-11-9-19(10-12-21)28-22(15-33)29-37-25-7-2-3-8-26(25)39(29)30(23(28)16-34)38-31(41)20-6-4-5-18(13-20)14-24(35)32(42)43/h2-13,24H,14,17,35H2,1H3,(H,36,40)(H,38,41)(H,42,43)/t24-/m0/s1
InChi Key
MLNOOVGSMCJSCE-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $219

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    Product Description

    KMH-233 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 18.2 µM).1 It is selective for LAT1 over LAT2 (IC50 = >1,000 µM). KMH-233 (25 and 100 µM) reduces the viability of MCF-7 cells and enhances cell death induced by bestatin (Item Nos. 21217 | 70520) or cisplatin (Item No. 13119) in the same cells. It also reduces mTOR and NF-κB levels and induces apoptosis in MCF-7 cells when used at a concentration of 100 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huttunen, K.M., Gynther, M., Huttunen, J., et al. A selective and slowly reversible inhibitor of ʟ-type amino acid transporter 1 (LAT1) potentiates antiproliferative drug efficacy in cancer cells. J. Med. Chem. 59(12), 5740-5751 (2016).

    2. Markowicz-Piasecka, M., Huttunen, J., Montaser, A., et al. Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. Apoptosis 25(5-6), 426-440 (2020).