An inhibitor of MLKL and necroptosis
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TC 13172

Item No. 31034

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,7-dihydro-3-[3-(3-hydroxyphenyl)-2-propyn-1-yl]-1,7-dimethyl-8-(methylsulfonyl)-1H-purine-2,6-dione
CAS Number
2093393-05-4
Molecular Formula
C17H16N4O5S
Formula Weight
388.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1C2=C(N(C(N1C)=O)CC#CC3=CC=CC(O)=C3)N=C(N2C)S(C)(=O)=O
InChi Code
InChI=1S/C17H16N4O5S/c1-19-13-14(18-16(19)27(3,25)26)21(17(24)20(2)15(13)23)9-5-7-11-6-4-8-12(22)10-11/h4,6,8,10,22H,9H2,1-3H3
InChi Key
ZTQLCNOQWGSELY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $54

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    1 mg

    $103

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    5 mg

    $378

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    Product Description

    TC 13172 is a covalent inhibitor of mixed lineage kinase domain-like protein (MLKL).1 It is selective for MLKL over receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at 10 µM. TC 13172 inhibits necroptosis induced by TSZ, which is a combination of TNF-α, a Smac mimetic, and Z-VAD-FMK, in HT-29 cells (EC50 = 2 nM). It inhibits TSZ-induced oligomerization of MLKL and translocation of MLKL to the plasma membrane in HT-29 cells when used at a concentration of 100 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yan, B., Liu, L., Huang, S., et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chem. Commun. (Camb.) 53(26), 3637-3640 (2017).