An IKKβ NBD mimetic
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SR 12460

Item No. 31066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]-acetamide
CAS Number
2055101-66-9
Molecular Formula
C15H14ClF2N3O
Formula Weight
325.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 15 mg/ml
λmax
244, 288 nm
SMILES
FC1=CC(F)=CC(CCNCC(NC2=NC=C(C=C2)Cl)=O)=C1
InChi Code
InChI=1S/C15H14ClF2N3O/c16-11-1-2-14(20-8-11)21-15(22)9-19-4-3-10-5-12(17)7-13(18)6-10/h1-2,5-8,19H,3-4,9H2,(H,20,21,22)
InChi Key
MQWIKNJATTZAPQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $123

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    10 mg

    $222

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    25 mg

    $502

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 µM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in the mdx mouse model of Duchenne muscular dystrophy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, J., Zhang, L., Mu, X., et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-kB activation. PLoS Biol. 16(6), e2004663 (2018).