A SOD mimetic
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Imisopasem Manganese

Item No. 31112

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(PB-7-11-2344′3′)-dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]-manganese
CAS Number
218791-21-0
Synonyms
  • M40403
Molecular Formula
C21H35Cl2MnN5
Formula Weight
483.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 3 mg/ml
SMILES
[Cl-][Mn+2]1234([N]5=C6C[NH]1[C@@](CCCC7)([H])[C@]7([H])[NH]2CC[NH]3[C@@]8([H])[C@](CCCC8)([H])[NH]4CC5=CC=C6)[Cl-]
InChi Code
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1
InChi Key
WXEMWBBXVXHEPU-XNPJUPKFSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Imisopasem manganese is a nonpeptide superoxide dismutase (SOD) mimetic.1 It catalyzes dismutation of the superoxide anion with a catalytic rate constant of greater than 2 x 107 M-1s-1. Imisopasem manganese (1-10 mg/kg, i.v. bolus) reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and lactate dehydrogenase (LDH) in rats. It inhibits increases in lung and ileum myeloperoxidase (MPO) levels, indicating reduced neutrophil infiltration, and increases in plasma malondialdehyde (MDA), TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by splanchnic artery occlusion (SAO) when administered at doses of 0.1, 0.3, and 1 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salvemini, D., Wang, Z.Q., Zweier, J.L., et al. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 286(5438), 304-306 (1999).