An NMDA receptor antagonist
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Product Categories

Product Type

Small Molecule Modulators
Ion Channel Modulators
Blockers

Research Area

DQP1105

Item No. 31121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
CAS Number
380560-89-4
Molecular Formula
C29H24BrN3O4
Formula Weight
558.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: >50 mg/ml
λmax
232 nm
SMILES
CC1=CC=C2C(C(C3=CC=CC=C3)=C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)C(N2)=O)=C1
InChi Code
InChI=1S/C29H24BrN3O4/c1-17-7-12-22-21(15-17)27(19-5-3-2-4-6-19)28(29(37)31-22)23-16-24(18-8-10-20(30)11-9-18)33(32-23)25(34)13-14-26(35)36/h2-12,15,24H,13-14,16H2,1H3,(H,31,37)(H,35,36)
InChi Key
MVYNQMRZRULRIE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    DQP1105 is an NMDA receptor antagonist.1 It selectively inhibits glutamate-induced currents in Xenopus oocytes expressing rat NR2C and NR2D subunit-containing NMDA receptors (IC50s = 8.5 and 2.7 µM, respectively) over NR2A, NR2B, NRA1, and NRK2 subunit-containing receptors (IC50s = 206, 121, 198, and 153 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Acker, T.M., Yuan, H., Hansen, K.B., et al. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-?-aspartate receptor subunit-selective modulators. Mol. Pharmacol. 80(5), 782-795 (2011).