A TRPA1 agonist
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ASP7663

Item No. 31122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-acetic acid
CAS Number
1190217-35-6
Molecular Formula
C14H14FNO3
Formula Weight
263.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
224, 250, 255, 315 nm
SMILES
FC1=C2C(/C(C(N2CC(C)C)=O)=C\C(O)=O)=CC=C1
InChi Code
InChI=1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
InChi Key
RCVZUIGCNAAMIC-UXBLZVDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $37

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    5 mg

    $132

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    10 mg

    $229

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    25 mg

    $523

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    Product Description

    ASP7663 is a transient receptor potential ankyrin 1 (TRPA1) agonist.1 It induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPA1 (EC50s = 0.51, 0.54, and 0.5 µM, respectively) and stimulates serotonin (5-HT) release from QGP-1 enterochromaffin cells that endogenously express TRPA1 (EC50 = 72.5 µM). It reduces colonic transit time in mouse models of constipation induced by clonidine (Item No. 15949) or loperamide when administered orally at a dose of 1 mg/kg, an effect that can be blocked by vagotomy or the TRPA1 antagonist HC-030031 (Item No. 11923). ASP7663 (0.3 mg/kg, p.o.) reduces the number of abdominal contractions induced by colorectal distension in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kojima, R., Nozawa , K., Doihara, H., et al. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur. J. Pharmacol. 723, 288-293 (2014).