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Etonitazene-d5

Item No. 31134

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-ethoxy-d5-phenyl)methyl]-N,N-diethyl-5-nitro-1H-benzimidazole-1-ethanamine
Molecular Formula
C22H23D5N4O3
Formula Weight
401.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
232 nm
SMILES
CCN(CC)CCN1C2=CC=C([N+]([O-])=O)C=C2N=C1CC3=CC=C(OC([2H])([2H])C([2H])([2H])[2H])C=C3
InChi Code
InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3/i3D3,6D2
InChi Key
PXDBZSCGSQSKST-SBRIIUNQSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Etonitazene-d5 (Item No. 31134) is an analytical reference standard intended for use as an internal standard for the quantification of etonitazene (Item No. 21824) by GC- or LC-MS. Etonitazene is categorized as an opioid.1,2,3 Etonitazene has analgesic effects in mice.4 Etonitazene-d5 is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blanckaert, P., Cannaert, A., Van Uytfanghe, K., et al. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene. Drug Test. Anal. 12(4), 422-430 (2019).

    2. Moolten, M.S., Fishman, J.B., Chen, J.C., et al. Etonitazene: An opioid selective for the mu receptor types. Life Sci. 52(18), PL199-PL203 (1993).

    3. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    4. Ujváry, I., Christie, R., Evans-Brown, M., et al. DARK classics in chemical neuroscience: Etonitazene and related benzimidazoles. ACS Chem. Neurosci. 12(7), 1072-1092 (2021).

    Product Citations

    Nalakath, J., Palathinkal, A.B., Naduvilakkandy, R., et al. In vitro metabolism of metonitazene in camels: High-resolution mass spectrometric characterization for doping control. Rapid Commun. Mass Sp. 39, e10111 (2025).