An anti-choroidal neovascularization agent
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IMS 2186

Item No. 31157

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E)-2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one
CAS Number
1031206-36-6
Molecular Formula
C18H16O4
Formula Weight
296.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlEthanol: 1 mg/ml
SMILES
CC1=CC=C(OC/C(C2=O)=C\C3=CC=C(OC)C(O)=C3)C2=C1
InChi Code
InChI=1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
InChi Key
BZCADTHMZLYKAR-MDWZMJQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $81

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    10 mg

    $145

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    25 mg

    $317

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    Cayman Chemical
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    Product Description

    IMS 2186 is an anti-choroidal neovascularization agent.1 It inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines, including ovarian, lung, colon, and pancreatic cancer cells (IC50s = 0.3-3 µM). IMS 2186 (10 µM) decreases migration of THP-1 macrophages in wound healing and chamber assays. Subcutaneous administration of IMS 2186 (20 µg/animal) inhibits VEGF-induced blood vessel formation in a MatrigelTM plug assay in mice. It reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization when administered intravitreally at a dose of 100 µg/eye.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Falkenstein, I.A., Cheng, L., Wong-Staal, F., et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr. Eye Res. 33(7), 599-609 (2008).