An amino acid
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3-Methyl-L-histidine

Item No. 31165

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
368-16-1
Synonyms
  • 3-Methylhistidine
  • 3MH
Molecular Formula
C7H11N3O2
Formula Weight
169.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
214 nm
SMILES
CN1C(C[C@H](N)C(O)=O)=CN=C1CN1C(C[C@H](N)C(O)=O)=CN=C1
InChi Code
InChI=1S/C7H11N3O2/c1-10-4-9-3-5(10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1
InChi Key
JDHILDINMRGULE-LURJTMIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $49

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    100 mg

    $93

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    Product Description

    3-Methyl-L-histidine is an endogenous amino acid and a component of the skeletal muscle proteins actin and myosin.1,2,3 It is released during the catabolism of muscle fibrillar protein and excreted in urine.3 Urinary levels of 3-methyl-L-histidine are decreased in children with protein-energy malnutrition compared with well-nourished control subjects. 3-Methyl-L-histidine has been used as a biomarker of skeletal muscle catabolism.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lukaski, H.C., Mendez, J., Buskirk, E.R., et al. Relationship between endogenous 3-methylhistidine excretion and body composition. Am. J. Physiol. 240(3), E302-E307 (1981).

    2. Lowry, S.F., Horowitz, G.D., Jeevanandam, M., et al. Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in man. Ann. Surg. 202(1), 21-27 (1985).

    3. Nagabhushan, V.S., and Narasinga Rao, B.S. Studies on 3-methylhistidine metabolism in children with protein-energy malnutrition. Am. J. Clin. Nutr. 31(8), 1322-1327 (1978).