An internal standard for the quantification of miconazole
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Unlabeled Version(s)
15420Miconazole (nitrate)
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Miconazole-d5

Item No. 31175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy-d2]ethyl-d3]-1H-imidazole
CAS Number
1216653-50-7
Molecular Formula
C18H9Cl4D5N2O
Formula Weight
421.2
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC=C(C([2H])([2H])OC([2H])(C2=CC=C(Cl)C=C2Cl)C([2H])(N3C=CN=C3)[2H])C(Cl)=C1
InChi Code
InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2/i9D2,10D2,18D
InChi Key
BYBLEWFAAKGYCD-XJMIFHCFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Miconazole-d5 is intended for use as an internal standard for the quantification of miconazole (Item No. 15420) by GC- or LC-MS. Miconazole is an imidazole antifungal.1 It is active against C. parapsilosis, C. pseudotropicalis, C. albicans, C. neoformans, C. tropicalis, and C. guilliermondii (MICs = <0.1-10 µg/ml). It is also active against various Trichophyton species, A. fumigatus, A. niger, B. brasiliensis, and B. dermatitidis. Miconazole (160 mg/kg) prevents infection with T. mentagrophytes and M. canis in mice. It also reduces lesion size in a guinea pig model of C. albicans infection. Formulations containing miconazole have been used in the treatment of various fungal infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sawyer, P.R., Brogden, R.N., Pinder, R.M., et al. Miconazole: A review of its antifungal activity and therapeutic efficacy. Drugs 9(6), 406-423 (1975).