An essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis
Related Products
Alternative(s)
43985Choline (acetate)
Labeled Version(s)
36454Choline-d9 (chloride)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Choline (chloride)

Item No. 31178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N,N,N-trimethyl-ethanaminium, monochloride
CAS Number
67-48-1
Molecular Formula
C5H14NO • Cl
Formula Weight
139.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
OCC[N+](C)(C)C.[Cl-]
InChi Code
InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
InChi Key
SGMZJAMFUVOLNK-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 g

    $49

    Add

    100 g

    $86

    Add

    250 g

    $130

    Add

    500 g

    $190

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis.1,2,3,4 It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport.1 Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats.2 Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm.3 Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanders, L.M., and Zeisel, S.H. Choline: Dietary requirements and role in brain development. Nutr. Today 42(4), 181-186 (2007).

    2. Thomas, J.D., Garrison, M., and O'Neill, T.M. Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in rats. Neurotoxicol. Teratol. 26(1), 35-45 (2004).

    3. Derbyshire, E., and Obeid, R. Choline, neurological development and brain function: A systematic review focusing on the first 1000 days. Nutrients 12(6), 1731 (2020).

    4. Moretti, A., Paoletta, M., Liguori, S., et al. Choline: An essential nutrient for skeletal muscle. Nutrients 12(7), E2144 (2020).