A tricyclic antidepressant
Related Products
Isomer(s)
15904Nortriptyline (hydrochloride)
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Protriptyline (hydrochloride)

Item No. 31179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine, monohydrochloride
CAS Number
1225-55-4
Synonyms
  • Protryptyline
Molecular Formula
C19H21N • HCl
Formula Weight
299.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 3 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
294 nm
SMILES
CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3.Cl
InChi Code
InChI=1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H
InChi Key
OGQDIIKRQRZXJH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Protriptyline is a tricyclic antidepressant.1 It binds to the norepinephrine and serotonin (5-HT) transporters with Kd values of 1.41 and 19.6 nM, respectively. Protriptyline also binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively).2 It inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM).3 Protriptyline (1 mg/kg, i.v.) inhibits food-induced cataplexy in narcoleptic dogs.4 Formulations containing protriptyline have been used in the treatment of depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tatsumi, M., Groshan, K., Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340(2-3), 249-258 (1997).

    2. Richelson, E., and Nelson, A. Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J. Pharmacol. Exp. Ther. 230(1), 94-102 (1984).

    3. Schacht, U., and Heptner, W. Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes. Biochem. Pharmacol. 23(24), 3413-3422 (1974).

    4. Foutz, A.S., Delashaw, J.B., Jr., Guilleminault, C., et al. Monoaminergic mechanisms and experimental cataplexy. Ann. Neurol. 10(4), 369-376 (1981).