An AChE inhibitor and a prokinetic agent
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Itopride (hydrochloride)

Item No. 31183

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy-benzamide, monohydrochloride
CAS Number
122892-31-3
Molecular Formula
C20H26N2O4 • HCl
Formula Weight
394.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
213, 259 nm
SMILES
COC1=C(OC)C=CC(C(NCC2=CC=C(OCCN(C)C)C=C2)=O)=C1.Cl
InChi Code
InChI=1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
InChi Key
ZTOUXLLIPWWHSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $183

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    10 mg

    $333

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    25 mg

    $753

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    Product Description

    Itopride is an inhibitor of acetylcholinesterase (AChE; IC50 = 1.6 µM for rat stomach enzyme) and a prokinetic agent.1 It induces contractions in isolated rabbit duodenum when used at concentrations ranging from 1 to 100 µM and enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips.2,3 Itopride (100 mg/kg) enhances normal gastric antral motility and improves gastric antral hypomotility and delayed gastric emptying induced by clonidine (Item No. 15949) in rats.1 Formulations containing itopride have been used in the treatment of functional dyspepsia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawachi, M., Matsunaga, Y., Tanaka, T., et al. Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats. Eur. J. Pharmacol. 666(1-3), 218-225 (2011).

    2. Butt, A.I., Khan, B.T., Khan, A., et al. Ranitidine can potentiate the prokinetic effect of itopride at low doses- an in vitro study. J. Ayub Med. Coll. Abbottabad 29(4), 554-558 (2017).

    3. Ito, K., Kawachi, M., Matsunaga, Y., et al. Acotiamide hydrochloride, a therapeutic agent for functional dyspepsia, enhances acetylcholine-induced contraction via inhibition of acetylcholinesterase activity in circular muscle strips of guinea pig stomach. Drug Res. (Stuttg.) 66(4), 196-202 (2016).