An AMPA receptor antagonist
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IEM 1754

Item No. 31192

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine, dihydrobromide
CAS Number
162831-31-4
Molecular Formula
C16H30N2 • 2HBr
Formula Weight
412.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
NCCCCCNCC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.Br.Br
InChi Code
InChI=1S/C16H30N2.2BrH/c17-4-2-1-3-5-18-12-16-9-13-6-14(10-16)8-15(7-13)11-16;;/h13-15,18H,1-12,17H2;2*1H/t13-,14+,15-,16?;;
InChi Key
JMPHTNNJCZDROM-MZHWIIHPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $30

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    10 mg

    $57

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    25 mg

    $127

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    50 mg

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    Product Description

    IEM 1754 is an AMPA receptor antagonist.1 It inhibits inward currents in whole-cell patch-clamp assays using X. laevis oocytes (IC50 = 6 µM). IEM 1754 (0.5 or 3 mg/kg) inhibits kainate-induced tonic-clonic seizures and reduces mortality in mice.2 It increases movement activity but does not reduce freezing time in a mouse model of centrifugation-induced dyskinesia when administered at a dose of 5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Magazanik, L.G., Buldakova, S.L., Samoilova, M.V., et al. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J. Physiol. 505(Pt 3), 655-663 (1997).

    2. Serdyuk, S.E., and Gmiro, V.E. Combined blockade of α3β4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures. Bull. Exp. Biol. Med. 143(5), 611-613 (2007).

    3. Lukomskaya, N.Y., Zhabko, E.P., and Gmiro, V.E. The involvement of glutamatergic transmission in the mechanism of movement disorders induced by reversive rotation of white mice. Neurosci. Behav. Physiol. 30(5), 543-546 (2000).