An enantiomer of L-phenylalanine with analgesic activity
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Enantiomer(s)
31498L-Phenylalanine
Isomer(s)
422942-Amino-2-(p-tolyl)acetic Acid
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Product Categories

Product Type

Biochemicals
Amino Acids
Natural

Research Area

Neuroscience
Pain Research

D-Phenylalanine

Item No. 31194

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
673-06-3
Synonyms
  • D-(+)-Phenylalanine
  • (R)-Phenylalanine
Molecular Formula
C9H11NO2
Formula Weight
165.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
SMILES
OC([C@H](N)CC1=CC=CC=C1)=O
InChi Code
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1
InChi Key
COLNVLDHVKWLRT-MRVPVSSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $68

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    25 g

    $103

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    100 g

    $186

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    Product Description

    D-Phenylalanine is an enantiomer of the essential amino acid L-phenylalanine and has analgesic activity.1,2 In vivo, D-phenylalanine (125 mg/kg) increases the latency to paw licking in a hot plate test in mice, an effect that can be reversed by naloxone.1 It also enhances acupuncture-induced analgesia in rabbits.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, R.S.S., and Pomeranz, B. Correlation of genetic differences in endorphin systems with analgesic effects of D-amino acids in mice. Brain Res. 177(3), 583-587 (1979).

    2. Han, J., Zhang, Y., Tang, J., et al. Augmentation of acupuncture analgesia by peptidase inhibitor D-phenylalanine in rabbits. Acta Zool. Sin. (1981).