An NMDA co-agonist
Related Products
Enantiomer(s)
33561L-Serine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

D-Serine

Item No. 31197

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
312-84-5
Synonyms
  • NSC 77689
  • (R)-Serine
Molecular Formula
C3H7NO3
Formula Weight
105.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
SMILES
OC[C@@H](N)C(O)=O
InChi Code
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChi Key
MTCFGRXMJLQNBG-UWTATZPHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $90

    Add

    50 g

    $158

    Add

    100 g

    $246

    Add

    250 g

    $523

    Add
    Product Description

    D-Serine is the dextrorotary isomer of the non-essential amino acid L-serine and a co-agonist of NMDA receptors.1 It is formed by conversion of L-serine by serine racemase and found primarily in the brain.2,3 D-Serine binds to the glycine site of the NMDA receptor and potentiates glutamate-induced currents in oocytes expressing various subunit combinations (EC50s = 0.17-0.32 µM) more potently than glycine.1,3 It reverses deficits in prepulse inhibition with prepulses of 69 and 73 decibels (dB), but not 81 dB, and increases the time spent in the target quadrant of the Morris water maze in mice with a mutant form of serine racemase (SrrY269*) when administered at a dose of 600 mg/kg.4 Serum levels of D-serine are decreased in patients with schizophrenia.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsui, T., Sekiguchi, M., Hashimoto, A., et al. Functional comparison of ᴅ-serine and glycine in rodents: The effect on cloned NMDA receptors and the extracellular concentration. J. Neurochem. 65(1), 454-458 (1995).

    2. Xia, M., Liu, Y., Figueroa, D.J., et al. Characterization and localization of a human serine racemase. Brain Res. Mol. Brain Res. 125(1-2), 96-104 (2004).

    3. Mothet, J.P., Parent, A.T., Wolosker, H., et al. ᴅ-Serine is an endogenous ligand for the glycine site of the N-methyl-ᴅ-aspartate receptor. Proc. Natl. Acad. Sci. USA 97(9), 4926-4931 (2000).

    4. Labrie, V., Fukumura, R., Rastogi, A., et al. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum. Mol. Genet. 18(17), 3227-3243 (2009).

    5. Cho, S.-E., Na, K.-S., Cho, S.-J., et al. Low ᴅ-serine levels in schizophrenia: A systematic review and meta-analysis. Neurosci. Lett. 634, 42-51 (2016).