Capsanthin

Capsanthin is a carotenoid that has been found in C. annuum and has diverse biological activities.^1,2,3 It reduces hydrogen peroxide-induced production of reactive oxygen species (ROS) and phosphorylation of ERK and p38 and prevents hydrogen peroxide-induced inhibition of gap junction intercellular communication in WB-F344 rat liver epithelial cells.¹ Capsanthin (0.2 mg/animal) reduces the number of colonic aberrant crypt foci and preneoplastic lesions in a rat model of N-methylnitrosourea-induced colon carcinogenesis.² It also reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).³

WARNING This product is not for human or veterinary use.

1. Kim, J.S., Lee, W.M., Rhee, H.C., et al. Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chem. Biol. Interact. 254, 146-155 (2016).

2. Narisawa, T., Fukaura, Y., Hasebe, M., et al. Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc. Soc. Exp. Biol. Med. 224(2), 116-122 (2000).

3. Horie, S., Okuda, C., T., Y., et al. Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids 45(8), 713-721 (2010).