A pigment with diverse biological activities
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Hydroxysafflor Yellow A

Item No. 31204

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-di-β-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-2,5-cyclohexadien-1-one
CAS Number
78281-02-4
Synonyms
  • Safflomin A
Molecular Formula
C27H32O16
Formula Weight
612.5
Purity
≥85%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
245, 407 nm
SMILES
OC(C([C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)(O)C(O)=C2C(/C=C/C3=CC=C(O)C=C3)=O)=C([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C2=O
InChi Code
InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-30,32-33,35-41H,7-8H2/b6-3+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1
InChi Key
LIPJRCGLQNIXGO-ONZBGLOFSA-N
Origin
Plant/Carthamus tinctorius
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $481

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    Product Description

    Hydroxysafflor yellow A is a pigment that has been found in C. tinctorius and has diverse biological activities.1,2,3,4 It inhibits LPS-induced increases in NF-κB levels and production of nitric oxide (NO), IL-1β, and TNF-α in primary mouse embryonic mesencephalic cultures when used at concentrations of 40 and 160 µM.2 Hydroxysafflor yellow A (1 and 3 mg/kg) decreases mean arterial pressure (MAP) and heart rate in anesthetized normotensive or spontaneously hypertensive rats.3 It reduces infarct volume and serum superoxide dismutase (SOD) activity in a rat model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 2, 4, and 8 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ao, H., Feng, W., and Peng, C. Hydroxysafflor yellow A: A promising therapeutic agent for a broad spectrum of diseases. Evid. Based Complement. Alternat. Med. 8259280, (2018).

    2. Wang, T., Ding, Y.-X., He, J., et al. Hydroxysafflor yellow A attenuates lipopolysaccharide-induced neurotoxicity and neuroinflammation in primary mesencephalic cultures. Molecules 23(5), 1210 (2018).

    3. Nie, P.-H., Zhang, L., Zhang, W.-H., et al. The effects of hydroxysafflor yellow A on blood pressure and cardiac function. J. Ethnopharmacol. 139(3), 746-750 (2012).

    4. Wei, X., Liu, H., Sun, X., et al. Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action. Neurosci. Lett. 386(1), 58-62 (2005).