Isovitexin

Isovitexin is a C-glycosylated flavone that has been found in Patrinia villosa and has diverse biological activities.^1,2,3,4,5 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC₅₀ = 370 µg/ml).² Isovitexin (50 and 100 µg/ml) is cytotoxic to HepG2 hepatic, MCF-7 breast, and HCT116 colorectal cancer cells.³ It inhibits LPS-induced production of TNF-α and IL-6 and decreases inducible nitric oxide synthase (iNOS) and COX-2 levels in RAW 264.7 cells when used at a concentration of 50 µg/ml.⁴ Isovitexin (200 µg/ml) reduces cytotoxicity induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells.⁵

WARNING This product is not for human or veterinary use.

1. He, M., Min, J.-W., Kong, W.-L., et al. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia 115, 74-85 (2016).

2. Zhang, J., Yuan, K., Zhou, W.-L., et al. Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. Pharmacogn. Mag. 7(25), 35-39 (2011).

3. Mohammed, R.S., Zeid, A.H.A., Hawary, S.S.E., et al. Flavonoid constituents, cytotoxic and antioxidant activities of Gleditsia triacanthos L. leaves. Saudi J. Biol. Sci. 21(6), 547-553 (2014).

4. Lv, H., Yu, Z., Zheng, Y., et al. Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating HO-1/Nrf2 pathways. Int. J. Biol. Sci. 12(1), 72-86 (2016).

5. Guimarães, C.C.O., D.D., Valdevite, M., Fachin Saltoratto, A.L., et al. The glycosylated flavonoids vitexin, isovitexin, and quercetrin isolated from Serjania erecta Radlk (Sapindaceae) leaves protect PC12 cells against amyloid-β₂5-35 peptide-induced toxicity. Food Chem. Toxicol. 86, 88-94 (2015).