An inhibitor of CYP4Z1
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CAY10770

Item No. 31216

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(1H-benzotriazol-1-ylamino)-octanoic acid
CAS Number
2428734-45-4
Molecular Formula
C14H20N4O2
Formula Weight
276.3
Purity
≥98%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlEthanol: 1 mg/mlMethyl Acetate: 1 mg/ml
SMILES
OC(CCCCCCCNN1N=NC2=C1C=CC=C2)=O
InChi Code
InChI=1S/C14H20N4O2/c19-14(20)10-4-2-1-3-7-11-15-18-13-9-6-5-8-12(13)16-17-18/h5-6,8-9,15H,1-4,7,10-11H2,(H,19,20)
InChi Key
XRQULSHHDALTQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

    $69

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    500 µg

    $127

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    1 mg

    $238

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    Product Description

    CAY10770 is an inhibitor of the cytochrome P450 (CYP) isoform CYP4Z1 (IC50 = 5.9 µM).1 It is selective for CYP4Z1 over CYP4A11, CYP4F2, CYP4F3a, CYP4F3b (IC50s = 187-282 µM) but does inhibit CYP4F8 and CYP4F12 (IC50s = 167 and 91 µM, respectively). CAY10770 (3 µM) inhibits the production of 14(15)-EET, 19-HETE, and 14(15)-DiHET by 83, 86, and 80%, respectively, in T47D breast cancer cells expressing CYP4Z1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kowalski, J.P., McDonald, M.G., Pelletier, R.D., et al. Design and characterization of the first selective and potent mechanism-based inhibitor of cytochrome P450 4Z1. J. Med. Chem. 63(9), 4824-4836 (2020).