A Kir2 channel inhibitor
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ML-133 (hydrochloride)

Item No. 31232

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-methoxyphenyl)methyl]-1-naphthalenemethanamine, monohydrochloride
CAS Number
1222781-70-5
Molecular Formula
C19H19NO • HCl
Formula Weight
313.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
λmax
224 nm
SMILES
COC(C=C1)=CC=C1CNCC2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
InChi Key
NGQIBUUFXDPHKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    25 mg

    $424

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    50 mg

    $740

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    Product Description

    ML-133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively).1 It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively). ML-133 (10 and 30 nmol/animal) prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, H.-R., Wu, M., Yu, H., et al. Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133. ACS Chem. Biol. 6(8), 845-856 (2011).

    2. Shi, Y., Chen, Y., and Wang, Y. Kir2.1 channel regulation of glycinergic transmission selectively contributes to dynamic mechanical allodynia in a mouse model of spared nerve injury. Neurosci Bull. 35(2), 301-314 (2019).