A Kir2 channel inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ML-133 (hydrochloride)

Item No. 31232

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-methoxyphenyl)methyl]-1-naphthalenemethanamine, monohydrochloride
CAS Number
1222781-70-5
Molecular Formula
C19H19NO • HCl
Formula Weight
313.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
λmax
224 nm
SMILES
COC(C=C1)=CC=C1CNCC2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H
InChi Key
NGQIBUUFXDPHKT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $107

    Add

    10 mg

    $193

    Add

    25 mg

    $424

    Add

    50 mg

    $740

    Add
    Product Description

    ML-133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively).1 It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively). ML-133 (10 and 30 nmol/animal) prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, H.-R., Wu, M., Yu, H., et al. Selective inhibition of the Kir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133. ACS Chem. Biol. 6(8), 845-856 (2011).

    2. Shi, Y., Chen, Y., and Wang, Y. Kir2.1 channel regulation of glycinergic transmission selectively contributes to dynamic mechanical allodynia in a mouse model of spared nerve injury. Neurosci Bull. 35(2), 301-314 (2019).