A tetrapeptide μ-opioid receptor agonist
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Bilaid A

Item No. 31242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanyl-D-valyl-L-valyl-D-phenylalanine
CAS Number
2393865-97-7
Synonyms
  • H-FVVF-OH
  • H-L-Phe-D-Val-L-Val-D-Phe-OH
Molecular Formula
C28H38N4O5
Formula Weight
510.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C(N[C@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@H](CC1=CC=CC=C1)C(O)=O)=O)=O)[C@@H](N)CC2=CC=CC=C2
InChi Code
InChI=1S/C28H38N4O5/c1-17(2)23(26(34)30-22(28(36)37)16-20-13-9-6-10-14-20)32-27(35)24(18(3)4)31-25(33)21(29)15-19-11-7-5-8-12-19/h5-14,17-18,21-24H,15-16,29H2,1-4H3,(H,30,34)(H,31,33)(H,32,35)(H,36,37)/t21-,22+,23-,24+/m0/s1
InChi Key
DEUGGGVTLCYZPU-UARRHKHWSA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $262

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    5 mg

    $976

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    Product Description

    Bilaid A is a tetrapeptide agonist of the μ-opioid receptor (Ki = 3.1 μM using HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation in HEK293 cells expressing the human μ-opioid receptor by 21% when used at a concentration of 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dekan, Z., Sianati, S., Yousuf, A., et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proc. Natl. Acad. Sci. USA 116(44), 22353-22358 (2019).