A tetrapeptide µ-opioid receptor agonist
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Isomer(s)
31244Bilaid B
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Bilaid C

Item No. 31246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-D-valyl-L-valyl-D-phenylalanine
CAS Number
2393866-13-0
Synonyms
  • H-L-Tyr-D-Val-L-Val-D-Phe
  • H-YVVF
Molecular Formula
C28H38N4O6
Formula Weight
526.6
Purity
≥95%
Formulation
A solid
SMILES
O=C(N[C@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@H](CC1=CC=CC=C1)C(O)=O)=O)=O)[C@@H](N)CC2=CC=C(O)C=C2
InChi Code
InChI=1S/C28H38N4O6/c1-16(2)23(26(35)30-22(28(37)38)15-18-8-6-5-7-9-18)32-27(36)24(17(3)4)31-25(34)21(29)14-19-10-12-20(33)13-11-19/h5-13,16-17,21-24,33H,14-15,29H2,1-4H3,(H,30,35)(H,31,34)(H,32,36)(H,37,38)/t21-,22+,23-,24+/m0/s1
InChi Key
QEPUDTSAZMRYEH-UARRHKHWSA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $229

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    5 mg

    $905

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    Product Description

    Bilaid C is a tetrapeptide µ-opioid receptor agonist (Ki = 210 nM in HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human µ-opioid receptor when used at a concentration of 10 µM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the µ-opioid receptor (EC50 = 4.2 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dekan, Z., Sianati, S., Yousuf, A., et al. A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. Proc. Natl. Acad. Sci. USA 116(44), 22353-22358 (2019).