An internal standard for the quantification of adefovir
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Unlabeled Version(s)
18650Adefovir
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Adefovir-d4

Item No. 31315

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[[2-(6-amino-9H-purin-9-yl)ethoxy-1,1,2,2-d4]methyl]-phosphonic acid
CAS Number
1190021-70-5
Synonyms
  • PMEA-d4
Molecular Formula
C8H8D4N5O4P
Formula Weight
277.2
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
[2H]C([2H])(N1C=NC2=C(N)N=CN=C21)C([2H])([2H])OCP(O)(O)=O
InChi Code
InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)/i1D2,2D2
InChi Key
SUPKOOSCJHTBAH-LNLMKGTHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    Product Description

    Adefovir-d4 is intended for use as an internal standard for the quantification of adefovir (Item No. 18650) by GC- or LC-MS. Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Item No. 28373).1 Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).2 It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and varicella zoster virus (VZV; EC50 = 10 µg/ml in human embryonic lung fibroblasts).3 Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5.4 It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.5

    WARNING This product is not for human or veterinary use.