An internal standard for the quantification of vapendavir
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Unlabeled Version(s)
30546Vapendavir
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Vapendavir-d5

Item No. 31320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(ethoxy-d5)-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-1,2-benzisoxazole
CAS Number
2738376-73-1
Synonyms
  • BTA798-d5
Molecular Formula
C21H21D5N4O3
Formula Weight
387.5
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleDMSO: SolubleMethanol: SolubleMethanol: Soluble
SMILES
CC1=CC=C(N=N1)N(CC2)CCC2CCOC3=CC=C(C(OC([2H])([2H])C([2H])([2H])[2H])=NO4)C4=C3
InChi Code
InChI=1S/C21H26N4O3/c1-3-26-21-18-6-5-17(14-19(18)28-24-21)27-13-10-16-8-11-25(12-9-16)20-7-4-15(2)22-23-20/h4-7,14,16H,3,8-13H2,1-2H3/i1D3,3D2
InChi Key
DKSVBVKHUICELN-WNWXXORZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Vapendavir-d5 is intended for use as an internal standard for the quantification of vapendavir (Item No. 30546) by GC- or LC-MS. Vapendavir is a capsid-binding antiviral agent.1,2 It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50 = 7.3 ng/ml).1 Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50 value of 0.7 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feil, S.C., Hamilton, S., Krippner, G.Y., et al. An orally available 3-ethoxybenzisoxazole capsid binder with clinical activity against human rhinovirus. ACS Med. Chem. Lett. 3(4), 303-307 (2012).

    2. Tijsma, A., Franco, D., Tucker, S., et al. The capsid binder vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob. Agents Chemother. 58(11), 6990-6992 (2014).