A pyran with diverse biological activities
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Chelidonic Acid

Item No. 31324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-oxo-4H-pyran-2,6-dicarboxylic acid
CAS Number
99-32-1
Synonyms
  • NSC 3979
Molecular Formula
C7H4O6
Formula Weight
184.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
λmax
220, 272 nm
SMILES
O=C1C=C(C(O)=O)OC(C(O)=O)=C1
InChi Code
InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12)
InChi Key
PBAYDYUZOSNJGU-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities.1,2,3 It inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM).2 Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-α levels, colonic COX-2 and prostaglandin E2 (PGE2; Item No. 14010) levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. 23250).1 It inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, D.-S., Kim, S.-J., Kim, M.-C., et al. The therapeutic effect of chelidonic acid on ulcerative colitis. Biol. Pharm. Bull. 35(5), 666-671 (2012).

    2. Porter, T.G., and Martin, C.L. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem. Pharmacol. 34(23), 4145-4150 (1985).

    3. Oh, H.-A., Kim, H.-M., and Jeong, H.-J. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Int. Immunopharmacol. 11(1), 39-45 (2011).